Rohan N. Shah , Adrian T. Grzybowski, Evan M. Cornett, Andrea L. Johnstone, Bradley M. Dickson, Brandon A. Boone, Marcus A. Cheek, Martis W. Cowles, Danielle Maryanski, Matthew J. Meiners, Rochelle L. Tiedemann, Robert M. Vaughan, Neha Arora, Zu-Wen Sun, Scott B. Rothbart, Michael-Christopher Keogh, Alexander J. Ruthenburg
Molecular Cell · 2018 · Cell Press
This study evaluates 52 commercial antibodies used to investigate histone methylation. Researchers find that many antibodies cannot reliably distinguish methylation forms, potentially leading to misleading biological interpretations. The findings highlight the importance of antibody validation for improving reproducibility and accuracy in epigenetic research.
Biological Sciences · Cell Biology
Journal Article
University of Chicago
United States
YouTube · 3:05
Animated explainer · English